By Li Di,Edward H Kerns
ISBN-10: 0123695201
ISBN-13: 9780123695208
The authors describe how houses have an effect on in vivo pharmacological job and effect in vitro assays. person drug-like houses are mentioned from a realistic viewpoint, corresponding to solubility, permeability and metabolic balance, with reference to primary figuring out, purposes of estate information in drug discovery and examples of structural variations that experience completed enhanced estate functionality. The authors additionally evaluation a variety of tools for the screening (high throughput), prognosis (medium throughput) and in-depth (low throughput) research of drug properties.
* Serves as a vital operating guide geared toward scientists and scholars in medicinal chemistry
* presents sensible, step by step advice on estate basics, results, structure-property relationships, and constitution amendment suggestions
* Discusses advancements in pharmacokinetics from a pragmatic chemist's standpoint
Read Online or Download Drug-like Properties: Concepts, Structure Design and Methods: from ADME to Toxicity Optimization PDF
Similar organic chemistry books
Enzymes in motion is a well timed survey of a latest improvement in natural chemistry. it really is transparent that bioreagents call for that natural chemists imagine another way. in the event that they achieve this, they will open up new avenues of fascinating, new chemistry that would allow difficulties to be solved in a chic means.
The Alkaloids: Chemistry and Pharmacology, Vol. 45 by Arnold Brossi PDF
The world over acclaimed for greater than forty years, this serial, based by way of the overdue Professor R. H. F. Manske, maintains to supply amazing insurance of the swiftly increasing box of the chemotaxonomy, constitution elucidation, synthesis, biosynthesis, and biology of all periods of alkaloids from larger and reduce crops, marine origins, or numerous terrestrial animals.
Brian S. Fulton's Drug Discovery for the Treatment of Addiction: Medicinal PDF
With habit a key objective for drug discovery efforts, this e-book fills a big and well timed desire for medicinal chemists who have to comprehend advanced neuroscience matters. the writer illustrates medicinal chemistry's widespread position in treating dependancy and covers particular medicinal drugs of abuse together with narcotics, stimulants, depressants, nicotine, and marijuana.
New PDF release: Handbook of Green Chemistry, Green Processes, Green
The shift in the direction of being as environmentally-friendly as attainable has ended in the necessity for this crucial quantity relating to eco-friendly nanoscience. Edited through emerging stars in the neighborhood, Alvise Perosa and Maurizio Selva, this can be a vital source for a person wishing to achieve an knowing of the area of eco-friendly chemistry, in addition to for chemists, environmental businesses and chemical engineers.
- The Privileged Pincer-Metal Platform: Coordination Chemistry & Applications (Topics in Organometallic Chemistry)
- Phosphorus Heterocycles II (Topics in Heterocyclic Chemistry)
- N-Heterocyclic Carbenes: Effective Tools for Organometallic Synthesis
- Kinetics of Multistep Reactions (Comprehensive Chemical Kinetics)
Additional info for Drug-like Properties: Concepts, Structure Design and Methods: from ADME to Toxicity Optimization
Sample text
Drug-like Properties: Concepts, Structure Design and Methods: from ADME to Toxicity Optimization by Li Di,Edward H Kerns
by Anthony
4.5
