By Li Di,Edward H Kerns
The authors describe how houses have an effect on in vivo pharmacological job and effect in vitro assays. person drug-like houses are mentioned from a realistic viewpoint, corresponding to solubility, permeability and metabolic balance, with reference to primary figuring out, purposes of estate information in drug discovery and examples of structural variations that experience completed enhanced estate functionality. The authors additionally evaluation a variety of tools for the screening (high throughput), prognosis (medium throughput) and in-depth (low throughput) research of drug properties.
* Serves as a vital operating guide geared toward scientists and scholars in medicinal chemistry
* presents sensible, step by step advice on estate basics, results, structure-property relationships, and constitution amendment suggestions
* Discusses advancements in pharmacokinetics from a pragmatic chemist's standpoint
Read Online or Download Drug-like Properties: Concepts, Structure Design and Methods: from ADME to Toxicity Optimization PDF
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Additional info for Drug-like Properties: Concepts, Structure Design and Methods: from ADME to Toxicity Optimization
Drug-like Properties: Concepts, Structure Design and Methods: from ADME to Toxicity Optimization by Li Di,Edward H Kerns