Download e-book for kindle: Design and Analysis of Non-Inferiority Trials (Chapman & by Mark D. Rothmann,Rothmann

By Mark D. Rothmann,Rothmann

ISBN-10: 1584888040

ISBN-13: 9781584888048

The elevated use of non-inferiority research has been followed by way of a proliferation of study at the layout and research of non-inferiority reports. utilizing examples from actual medical trials, Design and research of Non-Inferiority Trials brings jointly this physique of analysis and confronts the problems curious about the layout of a non-inferiority trial. every one bankruptcy starts with a non-technical advent, making the textual content simply understood by means of these with out previous wisdom of this sort of trial.



Topics lined include:




  • A number of problems with non-inferiority trials, together with a number of comparisons, lacking facts, research inhabitants, using safeguard margins, the interior consistency of non-inferiority inference, using surrogate endpoints, trial tracking, and equivalence trials

  • Specific matters and research equipment whilst the information are binary, non-stop, and time-to-event

  • The background of non-inferiority trials and the layout and behavior issues for a non-inferiority trial

  • The power of facts of an efficacy discovering and the way to judge the impression measurement of an energetic keep an eye on therapy



A complete dialogue at the goal and concerns concerned with non-inferiority trials, Design and research of Non-inferiority Trials will help present and destiny scientists and statisticians at the optimum layout of non-inferiority trials and in assessing the standard of non-inferiority comparisons performed in practice.

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Design and Analysis of Non-Inferiority Trials (Chapman & Hall/CRC Biostatistics Series) by Mark D. Rothmann,Rothmann


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