Read e-book online Cell-Penetrating Peptides: Processes and Applications PDF

By Ulo Langel

ISBN-10: 0849311411

ISBN-13: 9780849311413

one of many significant issues of drug supply is the shortcoming of huge hydrophilic compounds to go through the lipid membrane of the mobile, hence making medicines akin to polypeptides and oligonucleotides of restricted healing worth. until eventually lately, the delivery of such molecules into the cytoplasmic and nuclear cubicles of residing cells appeared a distant aim. for that reason, the invention that peptides derived from the HIV Tat protein and homeodomain of the Antennapedia transcription issue (penetratin) can translocate around the plasma membrane of stay cells has spread out interesting new percentages in biomedical research.

This publication fills the necessity for a finished replace of the study relating those really good peptides, referred to as cell-penetrating peptides (CPPs), to which the drug molecule can connect and go through the telephone membrane. Divided into 3 elements, Cell-Penetrating Peptides: approaches and functions covers periods of cell-penetrating peptides; mechanisms of mobilephone penetration, interactions of cell-penetrating peptides with plasma membranes, and lipid versions; and functions of cell-penetrating peptides. those divisions hide all info from easy biochemistry to medical software, together with a transparent description of the overall principles for mobile uptake of the delivery peptides. The evaluation of labor during this zone will result in larger designed novel delivery peptides to accomplish the extra profitable program of CPPs in examine and therapy.

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Cell-Penetrating Peptides: Processes and Applications (Pharmacology and Toxicology: Basic and Clinical Aspects) by Ulo Langel

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