By Christian Behl,Christine Ziegler
ISBN-10: 3642451780
ISBN-13: 9783642451782
Aging represents a physiological and per se non-pathological and multifactorial method concerning a suite of key genes and mechanisms being prompted through diversified endogenous and exogenous components. given that getting older is an enormous threat think about reference to a number of human problems, it's more and more changing into a primary subject in biochemical and scientific learn. The plethora of theories on getting older – a few of which were mentioned for many years – are neither remoted nor contradictory yet in its place will be hooked up in a community of pathways and procedures on the mobile and molecular degrees. This publication summarizes the main fashionable and demanding ways, concentrating on telomeres, DNA harm and oxidative tension in addition to at the attainable position of foodstuff, the interaction among genes and atmosphere (epigenetics) and intracellular protein homeostasis and introduces a few genes that experience really prolonged lifestyles spans in animal types. Linking those varied determinants of getting older with affliction, this quantity goals to bare their a number of interdependencies. We see that there's no unmarried “perfect” thought of getting older and that in its place it truly is attainable to outline what the authors name the molecular getting older matrix of the mobilephone. a greater wisdom of its key mechanisms and the mutual connections among its parts will bring about a greater realizing of age-associated problems akin to Alzheimer’s disease.
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Cell Aging: Molecular Mechanisms and Implications for Disease (SpringerBriefs in Molecular Medicine) by Christian Behl,Christine Ziegler
by Ronald
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