By Alison L. Allan
The “cancer stem phone” speculation postulates that melanoma arises from a subpopulation of tumor-initiating cells or melanoma stem cells (CSCs). whereas the assumption of melanoma stem cells has been round for greater than 100 years, facts from the fields of hematology and melanoma biology has now confirmed the serious position of stem cells in hematological malignancies and instructed that those related mechanisms also are vital to the initiation, development, and remedy of sturdy cancers. medical and experimental experiences have proven that CSCs express many classical houses of standard stem cells, together with a excessive self-renewal potential and the power to generate heterogeneous lineages; the requirement for a particular “niche”/microenvironment to develop; and an elevated skill for self-protection opposed to harsh environments, pollution, and medicine.
Cancer Stem Cells in stable Tumors represents an in depth review of melanoma stem cells and their function in strong cancers. constituted of 24 chapters, this quantity will offer readers with a finished figuring out of this significant and evolving field.
Topics lined include:
- Introduction of the CSC hypothesis
- Historical views and the contributing classes from leukemia
- Current wisdom in regards to the id and function of CSCs in quite a few different types of stable melanoma together with breast, mind, colorectal, pancreatic, prostate, cancer, lung, ovarian, hepatocellular, and head and neck melanoma
- Molecular pathways all in favour of using CSC functionality, with a selected concentrate on the radical convergence of embryonic and tumorigenic signaling pathways
- In vitro and in vivo assays, version platforms, and imaging modalities for learning CSCs
- The medical value of CSCs for melanoma administration and remedy, together with very important implications for diagnosis, prediction, and remedy resistance
- Consideration of the debate surrounding the CSC speculation and significant unanswered questions during this field
This collective paintings used to be written via a gaggle of well known foreign specialists in melanoma biology, oncology, and/or stem cellphone biology. it is going to function a worthy source for confirmed researchers, professors, healthiness care pros, and scholars within the scientific and clinical neighborhood who're investigating stem cells and/or oncology.
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Cancer Stem Cells in Solid Tumors (Stem Cell Biology and Regenerative Medicine) by Alison L. Allan