Antisense Drug Technology: Principles, Strategies, and by Stanley T. Crooke PDF

By Stanley T. Crooke

ISBN-10: 0824705661

ISBN-13: 9780824705664

broadly revised and up-to-date, Antisense Drug expertise: ideas, thoughts, and purposes, moment Edition displays the logarithmic development made some time past 4 years of oligonucleotide-based treatments, and, particularly, antisense therapeutics and learn. analyzing classes realized from the scientific trials of first new release medicinal drugs, the ebook evaluates the expertise as a complete and gives new instructions and avenues of study and improvement.

Divided into 5 elements, the ebook starts with a radical advent to the mechanism of antisense drug motion together with the RNase H mechanism, small RNA silencing pathways, and the capability therapeutics of splice switching oligonucleotides. best researchers display the fundamentals of oligonucleotide therapeutics partially by way of delineating medicinal chemistry, pharmacokinetics, and supply routes similar to liposomal formulations for nucleic acid delivery.  half 3 information hybridization dependent medications and considers the dramatic advances represented by means of 2’ methoxyethyl chimeric antisense inhibitors and duplex RNA medicines. different chemical periods of substances and mechanisms of motion are defined partially 4 with additional discussions on bettering the second one new release antisense medicines. the ultimate half delves deeply into healing purposes. Contributing authors learn the possibility of antisense medicinal drugs for the relief of cardiovascular illnesses, metabolic illnesses, inflammatory illnesses, melanoma, neurological issues, and immune modulation.

Presenting a hugely designated, lucid dialogue of the striking advances within the box, Antisense Drug know-how: ideas, thoughts, and functions, moment Edition presents the platform for researchers to proceed to aggressively pursue the nice chance represented via this intriguing technology.

--This textual content refers back to the Hardcover edition.

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Antisense Drug Technology: Principles, Strategies, and Applications: Principles, Strategies and Applications by Stanley T. Crooke

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